Immediately block a known malicious file hash, IP address, or URL across all endpoints.
Create an Indicator of Compromise (IoC) with a "Block and Remediate" action.
Why: Provides a rapid, organization-wide containment mechanism that is faster than waiting for AV signature updates.
Harden endpoints by blocking common attack techniques (e.g., Office creating child processes).
Deploy Attack Surface Reduction (ASR) rules, starting in 'Audit' mode to assess impact before switching to 'Block'.
Why: ASR rules are a key preventative control. Audit mode is critical for preventing disruption to business applications during rollout.
Perform deep forensic investigation or manual remediation on a live endpoint.
Use the Live Response feature to establish a remote shell and collect forensic packages.
Why: Provides direct, real-time access to the device for running commands, collecting files, and running forensic scripts.
Reconstruct an attacker's actions on a specific compromised device.
Analyze the Device Timeline.
Why: Provides a detailed, chronological event log of all process, network, file, and registry activity on the endpoint.
Detect credential theft and lateral movement techniques like Pass-the-Hash/Ticket.
Deploy Microsoft Defender for Identity sensors on all Domain Controllers.
Why: Defender for Identity monitors on-prem AD authentication traffic directly, providing high-fidelity alerts for identity-based attacks.
Protect users from zero-day malware embedded in email attachments.
Configure a Safe Attachments policy with the Dynamic Delivery option.
Why: Detonates attachments in a sandbox to check for malicious behavior while delivering the email body immediately, balancing security and productivity.
Find and remove all instances of a phishing email from user mailboxes.
Use Threat Explorer (or Advanced Hunting) to search for the email and execute a soft or hard delete action.
Why: Threat Explorer is a powerful search and remediation tool to purge active threats from the mail system organization-wide.
Prevent data exfiltration by blocking downloads of sensitive files to unmanaged (non-compliant) devices.
Configure a Defender for Cloud Apps session policy using Conditional Access App Control.
Why: Acts as a reverse proxy to inspect and control user activity in real-time within a cloud app session, enforcing data access policies.
Automatically contain a widespread, active attack like human-operated ransomware.
Enable Automatic Attack Disruption in Microsoft Defender XDR.
Why: Uses cross-domain signals (XDR) to take decisive action at machine speed, such as disabling compromised user accounts and isolating devices.
Proactively search for threats across all XDR data (endpoint, email, identity, cloud apps).
Use Advanced Hunting with Kusto Query Language (KQL).
Why: Provides a powerful, query-based interface to hunt across 30 days of raw telemetry, enabling discovery of threats that evade standard detections.
Quickly understand the full scope of a complex incident involving multiple alerts and entities.
Analyze the incident's Attack Story or Investigation Graph.
Why: Consolidates and visualizes the entire attack chain, showing how an attacker moved from an initial entry point across different assets.
Extend Defender for Cloud workload protections to on-premises and multi-cloud servers.
Onboard the servers using Azure Arc, then enable the Defender for Servers plan.
Why: Azure Arc acts as a control plane bridge, projecting non-Azure resources into Azure so they can be managed and secured by Defender for Cloud.
Quickly understand the purpose and potential maliciousness of a complex script (e.g., PowerShell).
Paste the script into Security Copilot and ask for an analysis of its function and risk.
Why: Leverages generative AI to de-obfuscate and explain code, significantly speeding up artifact analysis without executing the script.
Immediately contain a compromised user account that is synchronized from on-premises AD.
Disable the account in on-premises Active Directory, then trigger an immediate AD Connect sync.
Why: For synchronized identities, on-premises AD is the source of authority. Disabling the account there is the most effective containment action.
Use threat intelligence in Microsoft Sentinel
Ingest external threat intelligence from a TIP using an industry-standard protocol.
Use the 'Threat Intelligence - TAXII' data connector in Sentinel.
Why: Connects to TAXII 2.x servers to automatically import STIX-formatted indicators, operationalizing threat intelligence.